The government appeals the grant of a sua sponte 18 U.S.C. § 3582(c)(2) motion to reduce Ronnie Maples’s sentence for violations of 21 U.S.C. §§ 841(a)(1) & (b)(l)(A)(iii) in (1) conspiring to distribute and possess with intent to distribute more than 50 grams of crack cocaine and (2) in distributing and possessing with intent to distribute more than 5 grams of crack cocaine.

Following the adoption of Amendment 706 to the United States Sentencing Guidelines (U.S.S.G.), 1 the district court reduced Maples’s 188-month sentence to 162 months. Although Maples had received a downward departure for substantial assistance according to U.S.S.G. § 5K1.1, his original guideline range of life imprisonment under § 5Gl.l(b) was based on a mandatory minimum, not on his initial base offense level under § 2D1.1. We have recently held that a defendant who was sentenced subject to a statutory mandatory minimum does not fall within the scope of Amendment 706, in spite of any § 5K1.1 downward departure. United States v. Williams, 549 F.3d 1337 (11th Cir. 2008). Thus, because Maples’s guideline range of mandatory life imprisonment was not reduced or otherwise affected by Amendment 706, the district court had no basis to award a further reduction to his sentence, regardless of its prior substantial assistance departure. 2 Therefore, the district *203 court erred as a matter of law in reducing Maples’s sentence based on that amendment.

REVERSED AND REMANDED.