Jesus Jaime Garcia-Hernandez (Garcia) appeals the sentence imposed following his guilty-plea conviction for conspiracy to distribute cocaine in violation of 21 U.S.C. §§ 841(a)(1) and 846. He challenges the district court’s calculation of his offense level under the United States Sentencing Guidelines. He does not address his waiv *753 er, pursuant to his plea agreement, of his right to appeal.

The record demonstrates that Garcia’s appeal waiver was informed and voluntary. See United States v. Portillo, 18 F.3d 290, 292-93 (5th Cir. 1994); United States v. Melancon, 972 F.2d 566, 567 (5th Cir. 1992). The only appeal rights reserved by Garcia were the right to appeal any upward departure imposed pursuant to U.S.S.G. § 5K2.0 and the right to raise constitutional challenges regarding the effectiveness of counsel or regarding prosecutorial misconduct. Garcia’s challenges to the district court’s calculation of his offense level are not appeal bases excepted from the waiver. See United States v. Gaitan, 171 F.3d 222, 223-24 (5th Cir. 1999).

Although the Government asserted the appeal waiver in its brief, defense counsel did not file a reply brief. He has therefore failed to address the threshold issue before this court. Garcia’s appeal is therefore without arguable merit and is DISMISSED as frivolous. See 5th Cir. R. 42.2; Howard v. King, 707 F.2d 215, 220 (5th Cir. 1983).

APPEAL DISMISSED AS FRIVOLOUS.