Gregory Rhodes appeals the district court’s denial of his motion for a sentence reduction following the Sentencing Commission’s decision to lower the Guidelines range for crack offenses. Because Rhodes was sentenced as a career offender and his sentence was not based on the crack guidelines, we AFFIRM.

I.

In 1991, Gregory Rhodes pled guilty to conspiracy to possess with the intent to distribute cocaine and cocaine base (i.e., “crack”). At his sentencing, Rhodes was determined to be a career offender under U.S.S.G. § 4B1.1. His Total Offense Level was found to be thirty-five, and his Criminal History Category was found to be VI, resulting in a Guidelines imprisonment range of 292-365 months. The district court sentenced him to 292 months in prison and the sentence was upheld on appeal.

In 2007, the Sentencing Guidelines were amended to reduce the base offense levels in U.S.S.G. § 2D1.1 for most crack offenses. U.S.S.G.App. C, amend. 706 (2007). In 2008, that amendment was made retroactive. U.S.S.G.App. C, amend. 713 (2008). Shortly thereafter, Rhodes filed an 18 U.S.C. § 3582(c)(2) motion to reduce his sentence. The court denied the motion due to Rhodes’ status as a career offender. Rhodes now appeals.

*439 II.

This is one of a long line of cases in which a defendant argues that his sentence was “based on” the crack guidelines of U.S.S.G. § 2D1.1 when, in fact, the defendant was sentenced as a career offender under U.S.S.G. § 4B1.1. This Court has repeatedly held that when a defendant is sentenced as a career offender, his sentence is based on the career offender guidelines alone; it is not based on the guidelines for the underlying offense. See, e.g., United States v. Payton, 617 F.3d 911, 914 (6th Cir. 2010); United States v. Bridgewater, 606 F.3d 258, 260-61 (6th Cir. 2010); United States v. Williams, 607 F.3d 1123, 1125-26 (6th Cir. 2010); United States v. Perdue, 572 F.3d 288, 292-93 (6th Cir. 2009). That holding finds its roots in the language of 18 U.S.C. § 3582(c)(2), which applies only to a defendant whose sentence was “based on” a subsequently-lowered “sentencing range.” See Perdue, 572 F.3d at 292. A district court’s mere calculation of the offense level under the crack guidelines does not render a defendant’s career offender designation inapplicable. Id. at 292-93. Nor does a district court’s downward departure from the career offender guidelines render a career offender designation inapplicable. Bridge-water, 606 F.3d at 261-62. When a defendant is sentenced as a career offender, the career offender guidelines do not simply supplement the crack guidelines; they supplant them.

Because Rhodes was sentenced as a career offender, and the career offender sentencing range has not been lowered, he is ineligible for relief under § 3582(c)(2). Accordingly, we AFFIRM.