*206 The Controlled Substances Act imposes a 20-year mandatory minimum sentence on a defendant who unlawfully distributes a Schedule I or II drug, when "death or serious bodily injury results from the use of such substance." 21 U.S.C. § 841 (a)(1), (b)(1)(A)-(C) (2012 ed.). We consider whether the mandatory-minimum provision applies when use of a covered drug supplied by the defendant contributes to, but is not a but-for cause of, the victim's death or injury.

I

Joshua Banka, a long-time drug user, died on April 15, 2010, following an extended drug binge. The episode began on the morning of April 14, when Banka smoked marijuana at a former roommate's home. Banka stole oxycodone pills from the roommate before departing and later crushed, cooked, and injected the oxycodone. Banka and his wife, Tammy Noragon Banka (Noragon), then met with petitioner Marcus Burrage and purchased one gram of heroin from him. Banka immediately cooked and injected some of the heroin and, after returning home, injected more heroin between midnight and 1 a.m. on April 15. Noragon went to sleep at around 5 a.m., shortly after witnessing Banka prepare another batch of heroin. When Noragon woke up a few hours later, she found Banka dead in the bathroom and called 911. A search of the couple's home and car turned up syringes, 0.59 grams of heroin, alprazolam and clonazepam tablets, oxycodone pills, a bottle of hydrocodone, and other drugs.

Burrage pleaded not guilty to a superseding indictment alleging two counts of distributing heroin in violation of § 841(a)(1). Only one of those offenses, count 2, is at issue here. (Count 1 related to an alleged distribution of heroin *207 five months earlier than the sale to Banka.) Count 2 alleged that Burrage unlawfully distributed heroin on April 14, 2010, and that "death ... resulted from the use of th[at] substance"-thus subjecting Burrage to the 20-year mandatory minimum of § 841(b)(1)(C).

Two medical experts testified at trial regarding the cause of Banka's death. Dr. Eugene Schwilke, a forensic toxicologist, determined that multiple drugs were present in Banka's system at the time of his death, including heroin metabolites, codeine, alprazolam, clonazepam metabolites, and oxycodone. (A metabolite is a "product of metabolism," Webster's New International Dictionary 1544 (2d ed. 1950), or, as the Court of Appeals put it, "what a drug breaks down into in the body," 687 F.3d 1015 , 1018, n. 2 (C.A.8 2012).) Although morphine, a heroin metabolite, was the only drug present at a level above the therapeutic range- i.e., the concentration normally present when a person takes a drug as prescribed-Dr. Schwilke could not say whether Banka would have lived had he not taken the heroin. Dr. Schwilke nonetheless concluded that heroin "was a contributing factor" in Banka's death, since it interacted with the other drugs to cause "respiratory and/or central nervous system depression." App. 196. The heroin, in other words, contributed to an overall effect that caused Banka to stop *886 breathing. Dr. Jerri McLemore, an Iowa state medical examiner, came to similar conclusions. She described the cause of death as "mixed drug intoxication" with heroin, oxycodone, alprazolam, and clonazepam all playing a "contributing" role. Id ., at 157. Dr. McLemore could not say whether Banka would have lived had he not taken the heroin, but observed that Banka's death would have been "[v]ery less likely." Id., at 171.

The District Court denied Burrage's motion for a judgment of acquittal, which argued that Banka's death did not "result from" heroin use because there was no evidence that heroin was a but-for cause of death. Id., at 30. The court *208 also declined to give Burrage's proposed jury instructions regarding causation. One of those instructions would have required the Government to prove that heroin use "was the proximate cause of [Banka's] death." Id., at 236. Another would have defined proximate cause as "a cause of death that played a substantial part in bringing about the death," meaning that "[t]he death must have been either a direct result of or a reasonably probable consequence of the cause and except for the cause the death would not have occurred." Id., at 238. The court instead gave an instruction requiring the Government to prove "that the heroin distributed by the Defendant was a contributing cause of Joshua Banka's death." Id., at 241-242. The jury convicted Burrage on both counts, and the court sentenced him to 20 years' imprisonment, consistent with § 841(b)(1)(C)'s prescribed minimum.

The Court of Appeals for the Eighth Circuit affirmed Burrage's convictions. 687 F.3d 1015 . As to the causation-in-fact element of count 2, the court held that the District Court's contributing-cause instruction was consistent with its earlier decision in United States v. Monnier, 412 F.3d 859 , 862 (C.A.8 2005). See 687 F.3d, at 1021 . As to proximate cause, the court held that Burrage's proposed instructions "d[id] not correctly state the law" because "a showing of 'proximate cause' is not required." Id., at 1020 (quoting United States v. McIntosh, 236 F.3d 968 , 972-973 (C.A.8 2001) ).

We granted certiorari on two questions: Whether the defendant may be convicted under the "death results" provision (1) when the use of the controlled substance was a "contributing cause" of the death, and (2) without separately instructing the jury that it must decide whether the victim's death by drug overdose was a foreseeable result of the defendant's drug-trafficking offense. 569 U.S. ----, 133 S.Ct. 2049 , 185 L.Ed.2d 884 (2013).

II

As originally enacted, the Controlled Substances Act, 84 Stat. 1242 , 21 U.S.C. § 801 et seq., "tied the penalties for *209 drug offenses to both the type of drug and the quantity involved, with no provision for mandatory minimum sentences." DePierre v. United States, 564 U.S. ----, ----, 131 S.Ct. 2225 , 2229, 180 L.Ed.2d 114 (2011). That changed in 1986 when Congress enacted the Anti-Drug Abuse Act, 100 Stat. 3207 , which redefined the offense categories, increased the maximum penalties and set minimum penalties for many offenders, including the "death results" enhancement at issue here. See id ., at 3207-4. With respect to violations involving distribution of a Schedule I or II substance (the types of drugs defined as the most dangerous and addictive 1 ) the Act imposes sentences ranging from 10 years to life imprisonment for large-scale distributions, *887 § 841(b)(1)(A), from 5 to 40 years for medium-scale distributions, § 841(b)(1)(B), and not more than 20 years for smaller distributions, § 841(b)(1)(C), the type of offense at issue here. These default sentencing rules do not apply, however, when "death or serious bodily injury results from the use of [the distributed] substance." § 841(b)(1)(A)-(C). In those instances, the defendant "shall be sentenced to a term of imprisonment which ... shall be not less than twenty years or more than life," a substantial fine, "or both." 2 Ibid. *210 Because the "death results" enhancement increased the minimum and maximum sentences to which Burrage was exposed, it is an element that must be submitted to the jury and found beyond a reasonable doubt. See Alleyne v. United States, 570 U.S. ----, ----, 133 S.Ct. 2151 , 2162-2163, 186 L.Ed.2d 314 (2013); Apprendi v. New Jersey, 530 U.S. 466 , 490, 120 S.Ct. 2348 , 147 L.Ed.2d 435 (2000). Thus, the crime charged in count 2 of Burrage's superseding indictment has two principal elements: (i) knowing or intentional distribution of heroin, § 841(a)(1), 3 and (ii) death caused by ("resulting from") the use of that drug, § 841(b)(1)(C).

III

A

The law has long considered causation a hybrid concept, consisting of two constituent parts: actual cause and legal cause. H. Hart & A. Honore, Causation in the Law 104 (1959). When a crime requires "not merely conduct but also a specified result of conduct," a defendant generally may not be convicted unless his conduct is "both (1) the actual cause, and (2) the 'legal' cause (often called the 'proximate cause') of the result." 1 W. LaFave, Substantive Criminal Law § 6.4(a), pp. 464-466 (2d ed. 2003) (hereinafter LaFave); see also ALI, Model Penal Code § 2.03, p. 25 (1985). Those two categories roughly coincide with the two questions on which we granted certiorari. We find it necessary to decide only the first: whether the use of heroin was the actual cause of Banka's death in the sense that § 841(b)(1)(C) requires.

The Controlled Substances Act does not define the phrase "results from," so we give it its ordinary meaning. See Asgrow Seed Co. v. Winterboer, 513 U.S. 179 , 187, 115 S.Ct. 788 , 130 L.Ed.2d 682 (1995). A thing "results" when it "[a]rise[s] as an effect, issue, or outcome from some action, process or design." 2 The New *211 Shorter Oxford English Dictionary 2570 (1993). "Results from" imposes, in other words, a requirement of actual causality. "In the usual course," this requires proof " 'that the harm would not have occurred' in the absence of-that is, *888 but for-the defendant's conduct." University of Tex. Southwestern Medical Center v. Nassar, 570 U.S. ----, ----, 133 S.Ct. 2517 , 2525, 186 L.Ed.2d 503 (2013) (quoting Restatement of Torts § 431, Comment a (1934)). The Model Penal Code reflects this traditional understanding; it states that "[c]onduct is the cause of a result" if "it is an antecedent but for which the result in question would not have occurred." § 2.03(1)(a). That formulation represents " the minimum requirement for a finding of causation when a crime is defined in terms of conduct causing a particular result." Id., Explanatory Note (emphasis added); see also United States v. Hatfield, 591 F.3d 945 , 948 (C.A.7 2010) (but for "is the minimum concept of cause"); Callahan v. Cardinal Glennon Hospital, 863 S.W.2d 852 , 862 (Mo. 1993) (same).

Thus, "where A shoots B, who is hit and dies, we can say that A [actually] caused B's death, since but for A's conduct B would not have died." LaFave 467-468 (italics omitted). The same conclusion follows if the predicate act combines with other factors to produce the result, so long as the other factors alone would not have done so-if, so to speak, it was the straw that broke the camel's back. Thus, if poison is administered to a man debilitated by multiple diseases, it is a but-for cause of his death even if those diseases played a part in his demise, so long as, without the incremental effect of the poison, he would have lived. See, e.g., State v. Frazier, 339 Mo. 966 , 974-975, 98 S.W.2d 707 , 712-713 (1936).

This but-for requirement is part of the common understanding of cause. Consider a baseball game in which the visiting team's leadoff batter hits a home run in the top of the first inning. If the visiting team goes on to win by a score of 1 to 0, every person competent in the English language and familiar with the American pastime would agree *212 that the victory resulted from the home run. This is so because it is natural to say that one event is the outcome or consequence of another when the former would not have occurred but for the latter. It is beside the point that the victory also resulted from a host of other necessary causes, such as skillful pitching, the coach's decision to put the leadoff batter in the lineup, and the league's decision to schedule the game. By contrast, it makes little sense to say that an event resulted from or was the outcome of some earlier action if the action merely played a nonessential contributing role in producing the event. If the visiting team wound up winning 5 to 2 rather than 1 to 0, one would be surprised to read in the sports page that the victory resulted from the leadoff batter's early, non-dispositive home run.

Where there is no textual or contextual indication to the contrary, courts regularly read phrases like "results from" to require but-for causality. Our interpretation of statutes that prohibit adverse employment action "because of" an employee's age or complaints about unlawful workplace discrimination is instructive. Last Term, we addressed Title VII's antiretaliation provision, which states in part:

"It shall be an unlawful employment practice for an employer ... to discriminate against any individual ... because he has opposed any practice made an unlawful employment practice by this subchapter, or because he has made a charge, testified, assisted, or participated in any manner in an investigation, proceeding, or hearing under this subchapter." 42 U.S.C. § 2000e-3(a) (2006 ed.) (emphasis added).

Given the ordinary meaning of the word "because," we held that § 2000e-3(a)"require[s] proof that the desire to retaliate *889 was [a] but-for cause of the challenged employment action." Nassar, supra, at ----, 133 S.Ct., at 2528. The same result obtained in an earlier case interpreting a provision in the Age Discrimination in Employment Act that makes it "unlawful for an employer ... *213 to discharge any individual or otherwise discriminate against any individual with respect to his compensation, terms, conditions, or privileges of employment, because of such individual's age." 29 U.S.C. § 623 (a)(1) (emphasis added). Relying on dictionary definitions of "[t]he words 'because of' "-which resemble the definition of " results from" recited above-we held that "[t]o establish a disparate-treatment claim under the plain language of [ § 623(a)(1) ] ... a plaintiff must prove that age was [a] 'but for' cause of the employer's adverse decision." Gross v. FBL Financial Services, Inc., 557 U.S. 167 , 176, 129 S.Ct. 2343 , 174 L.Ed.2d 119 (2009). 4

Our insistence on but-for causality has not been restricted to statutes using the term "because of." We have, for instance, observed that "[i]n common talk, the phrase 'based on' indicates a but-for causal relationship," Safeco Ins. Co. of America v. Burr, 551 U.S. 47 , 63, 127 S.Ct. 2201 , 167 L.Ed.2d 1045 (2007), and that "the phrase, 'by reason of,' requires at least a showing of 'but for' causation," Gross, supra, at 176 , 129 S.Ct. 2343 (citing Bridge v. Phoenix Bond & Indemnity Co., 553 U.S. 639 , 653-654, 128 S.Ct. 2131 , 170 L.Ed.2d 1012 (2008) ). See also Holmes v. Securities Investor Protection Corporation, 503 U.S. 258 , 265-268, 112 S.Ct. 1311 , 117 L.Ed.2d 532 (1992) (explaining that a statute permitting recovery for injuries suffered " 'by reason of' " the defendant's unlawful conduct "require[s] a showing that the defendant's violation ... was," among other things, "a 'but for' cause of his injury"). State courts, which hear and decide the bulk of the Nation's criminal matters, usually interpret similarly worded criminal statutes in the same manner.

*214 See, e.g., People v. Wood, 276 Mich.App. 669 , 671, 741 N.W.2d 574 , 575-578 (2007) (construing the phrase "[i]f the violation results in the death of another individual" to require proof of but-for causation (emphasis deleted)); State v. Hennings, 791 N.W.2d 828 , 833-835 (Iowa 2010) (statute prohibiting " 'offenses ... committed against a person or a person's property because of the person's race' " or other protected trait requires discriminatory animus to be a but-for cause of the offense); State v. Richardson, 295 N.C. 309 , 322-323, 245 S.E.2d 754 , 763 (1978) (statute requiring suppression of evidence " 'obtained as a result of' " police misconduct "requires, at a minimum," a but-for causal relationship between the misconduct and collection of the evidence).

In sum, it is one of the traditional background principles "against which Congress legislate[s]," Nassar, 570 U.S., at ----, 133 S.Ct., at 2525, that a phrase such as "results from" imposes a requirement of but-for causation. The Government argues, however, that distinctive problems associated with drug overdoses counsel in *890 favor of dispensing with the usual but-for causation requirement. Addicts often take drugs in combination, as Banka did in this case, and according to the National Center for Injury Prevention and Control, at least 46 percent of overdose deaths in 2010 involved more than one drug. See Brief for United States 28-29. This consideration leads the Government to urge an interpretation of "results from" under which use of a drug distributed by the defendant need not be a but-for cause of death, nor even independently sufficient to cause death, so long as it contributes to an aggregate force (such as mixed-drug intoxication) that is itself a but-for cause of death.

In support of its argument, the Government can point to the undoubted reality that courts have not always required strict but-for causality, even where criminal liability is at issue. The most common (though still rare) instance of this occurs when multiple sufficient causes independently, but concurrently, produce a result. See Nassar, supra, at ----, 133 S.Ct., at 2525;

*215 see also LaFave 467 (describing these cases as "unusual" and " numerically in the minority"). To illustrate, if "A stabs B, inflicting a fatal wound ; while at the same moment X, acting independently, shoots B in the head ... also inflicting [a fatal] wound ; and B dies from the combined effects of the two wounds," A will generally be liable for homicide even though his conduct was not a but-for cause of B's death (since B would have died from X's actions in any event). Id ., at 468 (italics omitted). We need not accept or reject the special rule developed for these cases, since there was no evidence here that Banka's heroin use was an independently sufficient cause of his death. No expert was prepared to say that Banka would have died from the heroin use alone.

Thus, the Government must appeal to a second, less demanding (but also less well established) line of authority, under which an act or omission is considered a cause-in-fact if it was a "substantial" or "contributing" factor in producing a given result. Several state courts have adopted such a rule, see State v. Christman, 160 Wash.App. 741 , 745, 249 P.3d 680 , 687 (2011) ; People v. Jennings, 50 Cal.4th 616 , 643, 114 Cal.Rptr.3d 133 , 237 P.3d 474 , 496 (2010) ; People v. Bailey, 451 Mich. 657 , 676-678, 549 N.W.2d 325 , 334-336 (1996) ; Commonwealth v. Osachuk, 43 Mass.App. 71 , 72-73, 681 N.E.2d 292 , 294 (1997), but the American Law Institute declined to do so in its Model Penal Code, see ALI, 39th Annual Meeting Proceedings 135-141 (1962); see also Model Penal Code § 2.03(1)(a). One prominent authority on tort law asserts that "a broader rule ... has found general acceptance: The defendant's conduct is a cause of the event if it was a material element and a substantial factor in bringing it about." W. Keeton, D. Dobbs, R. Keeton, & D. Owen, Prosser and Keeton on Law of Torts § 41, p. 267 (5th ed. 1984) (footnote omitted). But the authors of that treatise acknowledge that, even in the tort context, "[e]xcept in the classes of cases indicated" (an apparent reference to the situation where each of two causes is independently effective) "no case has been *216 found where the defendant's act could be called a substantial factor when the event would have occurred without it." Id., at 268. The authors go on to offer an alternative rule-functionally identical to the one the Government argues here-that "[w]hen the conduct of two or more actors is so related to an event that their combined conduct, viewed as a whole, is a but-for cause of the event, and application of the but-for rule to them individually would absolve all of them, the conduct of each is a cause in fact of the event." Ibid. Yet, as of 1984, "no judicial opinion ha[d] approved th[at] formulation." *891 Ibid., n. 40. The "death results" enhancement became law just two years later.

We decline to adopt the Government's permissive interpretation of § 841(b)(1). The language Congress enacted requires death to "result from" use of the unlawfully distributed drug, not from a combination of factors to which drug use merely contributed. Congress could have written § 841(b)(1)(C) to impose a mandatory minimum when the underlying crime "contributes to" death or serious bodily injury, or adopted a modified causation test tailored to cases involving concurrent causes, as five States have done, see Ala.Code § 13A-2-5(a) (2005) ; Ark.Code Ann. § 5-2-205 (2006); Me.Rev.Stat. Ann., Tit. 17-A, § 33 (2006) ; N.D. Cent. Code Ann. § 12.1-02-05 (Lexis 2012); Tex. Penal Code Ann. § 6.04 (West 2011). It chose instead to use language that imports but-for causality. Especially in the interpretation of a criminal statute subject to the rule of lenity, see Moskal v. United States, 498 U.S. 103 , 107-108, 111 S.Ct. 461 , 112 L.Ed.2d 449 (1990), we cannot give the text a meaning that is different from its ordinary, accepted meaning, and that disfavors the defendant.

B

The Government objects that the ordinary meaning of "results from" will "unduly limi[t] criminal responsibility" and "cannot be reconciled with sound policy." Brief for United States 24. We doubt that the requirement of but-for causation *217 for this incremental punishment will prove a policy disaster. A cursory search of the Federal Reporter reveals that but-for causation is not nearly the insuperable barrier the Government makes it out to be. See, e.g., United States v. Krieger, 628 F.3d 857 , 870-871 (C.A.7 2010) (affirming "death results" conviction based on expert testimony that, although the victim had several drugs in her system, the drug distributed by the defendant was a but-for cause of death); United States v. Webb, 655 F.3d 1238 , 1254-1255 (C.A.11 2011) ( per curiam ) (same). Moreover, even when the prosecution is unable to prove but-for causation, the defendant will still be liable for violating § 841(a)(1) and subject to a substantial default sentence under § 841(b)(1).

Indeed, it is more likely the Government's proposal that "cannot be reconciled with sound policy," given the need for clarity and certainty in the criminal law. The judicial authorities invoking a "substantial" or "contributing" factor test in criminal cases differ widely in their application of it. Compare Wilson v. State, 24 S.W. 409 , 410 (Tex.Crim.App. 1893) (an act is an actual cause if it "contributed materially" to a result, even if other concurrent acts would have produced that result on their own), with Cox v. State, 305 Ark. 244 , 248, 808 S.W.2d 306 , 309 (1991) (causation cannot be found where other concurrent causes were clearly sufficient to produce the result and the defendant's act was clearly insufficient to produce it) (applying Ark.Code Ann. § 5-2-205 (1987)). 5 Here the Government is uncertain about the precise application of the test that it proposes. Taken literally, its "contributing-cause" test would treat as a cause-in-fact every act or omission that makes a positive incremental contribution *218 , however small, to a particular result. See Brief for State of Alaska et al. as Amici Curiae 20; see also Black's Law Dictionary 250 (9th ed. 2009) *892 (defining "contributing cause" as "[a] factor that-though not the primary cause-plays a part in producing a result"). But at oral argument the Government insisted that its test excludes causes that are " not important enough" or "too insubstantial." Tr. of Oral Arg. 28. Unsurprisingly, it could not specify how important or how substantial a cause must be to qualify. See id., at 41-42. Presumably the lower courts would be left to guess. That task would be particularly vexing since the evidence in § 841(b)(1) cases is often expressed in terms of probabilities and percentages. One of the experts in this case, for example, testified that Banka's death would have been "[v]ery less likely" had he not used the heroin that Burrage provided. App. 171. Is it sufficient that use of a drug made the victim's death 50 percent more likely? Fifteen percent? Five? Who knows. Uncertainty of that kind cannot be squared with the beyond-a-reasonable-doubt standard applicable in criminal trials or with the need to express criminal laws in terms ordinary persons can comprehend. See United States v. L. Cohen Grocery Co., 255 U.S. 81 , 89-90, 41 S.Ct. 298 , 65 L.Ed. 516 (1921).

But in the last analysis, these always-fascinating policy discussions are beside the point. The role of this Court is to apply the statute as it is written-even if we think some other approach might " 'accor[d] with good policy.' " Commissioner v. Lundy, 516 U.S. 235 , 252, 116 S.Ct. 647 , 133 L.Ed.2d 611 (1996) (quoting Badaracco v. Commissioner, 464 U.S. 386 , 398, 104 S.Ct. 756 , 78 L.Ed.2d 549 (1984) ). As we have discussed, it is written to require but-for cause.

* * *

We hold that, at least where use of the drug distributed by the defendant is not an independently sufficient cause of the victim's death or serious bodily injury, a defendant cannot be liable under the penalty enhancement provision of *219 21 U.S.C. § 841 (b)(1)(C) unless such use is a but-for cause of the death or injury. The Eighth Circuit affirmed Burrage's conviction based on a markedly different understanding of the statute, see 687 F.3d, at 1020-1024 , and the Government concedes that there is no "evidence that Banka would have lived but for his heroin use," Brief for United States 33. Burrage's conviction with respect to count 2 of the superseding indictment is therefore reversed, and the case is remanded for further proceedings consistent with this opinion.

It is so ordered.

Justice GINSBURG, with whom Justice SOTOMAYOR joins, concurring in the judgment.

For reasons explained in my dissenting opinion in University of Tex. Southwestern Medical Center v. Nassar, 570 U.S. ----, ----, 133 S.Ct. 2517 , 2534-2547, 186 L.Ed.2d 503 (2013), I do not read "because of" in the context of antidiscrimination laws to mean "solely because of." See id., at ---- - ----, ---- - ----, 133 S.Ct., at 2544-2546, 2546-2547. And I do not agree that words "appear[ing] in two or more legal rules, and so in connection with more than one purpose, ha[ve] and should have precisely the same scope in all of them." Cook, " Substance" and "Procedure" in the Conflict of Laws, 42 Yale L.J. 333 , 337 (1933). But I do agree that "in the interpretation of a criminal statute subject to the rule of lenity," where there is room for debate, one should not choose the construction "that disfavors the defendant." Ante, at 891. Accordingly, I join the Court's judgment.